Senior Research Associate, Process Development
Company: Meet
Location: Santa Monica
Posted on: June 24, 2022
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Job Description:
ABOUTMy client is a pre-clinical stage biotechnology company
aiming to change the paradigm of treatment for solid cancers. They
are working to develop novel technologies to enable the engineering
of 'designer T cells' with neo-antigen specificities that display
an optimized ability to seek and destroy cancer cells.POSITION
SUMMARY We are seeking a highly motived, data-driven researcher to
join our Process Development (PD) team as a Senior Research
Associate. The successful candidate should have a knowledge of
basic immunology principles, bioprocess development, and cGMP
manufacturing. The candidate should also have experience in primary
cell culture (T cells preferred), in different formats including
flasks and bags. This role will support the development of a
clinical manufacturing process of engineered T cells with
patient-derived neo-antigen specific TCRs. The candidate will also
be part of a team involved in implementing technology and
participating in technology transfer to the clinical
setting.PRIMARY RESPONSIBILITIES:Execution of process development
studies to develop, optimize, scale-up and transfer cGMP
manufacturing processes --- Perform cell culture of T cells in
multiple formats including flasks, bags, and bioreactors ---
Collaborate within the project team to interpret study results and
contribute to technical discussions for subsequent study design.
--- Prepare and review experimental proposals, technical reports,
SOPs and manufacturing batch records. --- Work collaboratively
within PD group and cross-functionally with other groups to meat
Tech Ops organization goals --- Other responsibilities as
assignedQUALIFICATIONS: --- MS degree in Immunology, Cell Biology,
Molecular biology, Bioengineering, or relevant degrees with 1+
years relevant industry experience or BS degree with 2+ years
relevant industry experience. --- Experience in technical
development of cell and gene therapy or biologics in early and late
development setting --- Hands-on experience in cell and gene
therapy, specifically in T cells is highly desirable --- Experience
in Flow Cytometry his highly desired --- Knowledge of cGMP
manufacturing and regulations and practical experience in GMP
operations is highly desirable --- Knowledge of QbD, DOE and
appropriate statistical analysis for process development ---
Ability to think critically, analytically and have demonstrated
troubleshooting and problem-solving skills based on deductive
reasoning
Keywords: Meet, Santa Monica , Senior Research Associate, Process Development, Other , Santa Monica, California
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